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Academic Experts
Academic Experts
Dr. Reetika Debroy
Assistant Professor
reetika.debroy@jiit.ac.in
Biography

Dr. Reetika Debroy joined the Department of Biotechnology, Jaypee Institute of Information Technology as an Assistant Professor in August, 2024. She received her Ph.D. degree from Vellore Institute of Technology, Vellore, India, in October 2023. She was awarded with the Senior Research Fellowship sponsored by the Indian Council of Medical Research, Govt. of India (2022). She was appointed as a Teaching and Research Assistant in Institute of Technology, Vellore, India, from 2019-2022. She completed her M.Sc. in Applied Microbiology from Vellore Institute of Technology, Vellore, India, in 2019; and B.Sc. in Zoology from Gurucharan College (Affiliated to Assam University), Silchar, in 2017.

Research Highlights

Her doctoral research emphasized on identification and validation of therapeutic drug targets in opportunistic pathogens using integrated systems biology and structural bioinformatics methods. She performed her core research on formulating targeted-therapy strategies against antimicrobial resistance in nosocomial pathogens through genomic screenings, analysing high-throughput data, protein-protein interaction network studies, in- silico drug target optimizations, dynamics simulation studies and ligand optimization methods. She has expertise in several sub-domains of microbial informatics including whole genome analysis, genome annotation, phylogenetics, variant calling, transcriptomic data analysis, differential gene expression studies, interactomics (protein-protein interaction, gene-gene interaction, host-pathogen protein-protein interaction), functional enrichment analysis, gene ontology analysis, protein/gene clustering analysis, network topology analysis (centrality, degree, shortest path length), protein modelling, tertiary protein structure optimizations and validations, mutational analysis, druggability predictions, pharmacokinetic screening of ligands, ligand structure optimizations, virtual screening, molecular docking, molecular dynamics simulations and post-dynamics simulation studies, Monte Carlo simulations and principal component analysis.

Areas Of Interest
  • Structural Bioinformatics
  • Microbial Infections
  • Antimicrobial Resistance
  • Computer-aided Drug Discovery
Publications

  1. Debroy, R., & Ramaiah, S. (2023). Consolidated knowledge-guided computational pipeline for therapeutic intervention against bacterial biofilms-a review. Biofouling, 1-20. https://doi.org/10.1080/08927014.2023.2294763

  2. Naha, A., Debroy, R., Sharma, D., Shah, M. P., & Nath, S. (2023). Microbial fuel cell: A state-of-the-art and revolutionizing technology for efficient energy recovery. Cleaner and Circular Bioeconomy, 5, 100050. https://doi.org/10.1016/j.clcb.2023.100050.

  3. Debroy, R., & Ramaiah, S. (2023). Translational protein RpsE as an alternative target for novel nucleoside analogues to treat MDR Enterobacter cloacae ATCC 13047: network analysis and molecular dynamics study. World Journal of Microbiology and Biotechnology, 39(7), 187. https://doi.org/10.1007/s11274-023-03634-z

  4. Basu, S., Debroy, R., Kumar, H., Singh, H., Ramaiah, S., & Anbarasu, A. (2023). Bioactive phytocompounds against specific target proteins of Borrelia recurrentis responsible for louse‐borne relapsing fever: Genomics and structural bioinformatics evidence. Medical and Veterinary Entomology, 37(2), 213-218. https://doi.org/10.1111/mve.12623

  5. Basu, S., Ashok, G., Debroy, R., Ramaiah, S., Livingstone, P., & Anbarasu, A. (2023). Impact of the COVID-19 pandemic on routine vaccine landscape: A global perspective. Human Vaccines & Immunotherapeutics, 2199656. https://doi.org/10.1080/21645515.2023.2199656

  6. Debroy, R., & Ramaiah, S. (2022). MurC ligase of multi-drug resistant Salmonella Typhi can be inhibited by novel Curcumin derivative: Evidence from molecular docking and dynamics simulations. The International Journal of Biochemistry & Cell Biology, 151, 106279. https://doi.org/10.1016/j.biocel.2022.106279

  7. Basu, S., Varghese, R., Debroy, R., Ramaiah, S., Veeraraghavan, B., & Anbarasu, A. (2022). Non-steroidal anti-inflammatory drugs ketorolac and etodolac can augment the treatment against pneumococcal meningitis. Microbial Pathogenesis, 170, 105694. https://doi.org/10.1016/j.micpath.2022.105694

  8. Priyamvada, P., Debroy, R., Anbarasu, A., & Ramaiah, S. (2022). A comprehensive review on genomics, systems biology and structural biology approaches for combating antimicrobial resistance in ESKAPE pathogens. World Journal of Microbiology and Biotechnology, 38(9), 1-14. https://doi.org/10.1007/s11274-022-03343-z

  9. Naha, A., Banerjee, S., Debroy, R., Basu, S., Ashok, G., Priyamvada, P., ...& Ramaiah, S.(2022). Network metrics, structural dynamics and density functional theory calculations identified a novel Ursodeoxycholic Acid derivative against therapeutic target Parkin for Parkinson's disease. Computational and Structural Biotechnology Journal, 20, 4271-4287. https://doi.org/10.1016/j.csbj.2022.08.017

  10. Miryala, S. K., Basu, S., Naha, A., Debroy, R., Ramaiah, S., Anbarasu, A., & Natarajan, S. (2022). Datasets comprising the quality validations of simulated protein-ligand complexes and SYBYL docking scores of bioactive natural compounds as inhibitors of Mycobacterium tuberculosis protein-targets. Data in Brief, 42, 108146. https://doi.org/10.1016/j.dib.2022.108146

  11. Miryala, S HX: S. K., Basu, S., Naha, A., Debroy, R., Ramaiah, S., Anbarasu, A., & Natarajan, S. (2021). Identification of bioactive natural compounds as efficient inhibitors against Mycobacterium tuberculosis protein-targets: A molecular docking and molecular dynamics simulation study. Journal of Molecular Liquids, 117340. https://doi.org/10.1016/j.molliq.2021.117340

  12. Debroy, R., Miryala, S. K., Naha, A., Anbarasu, A., & Ramaiah, S. (2020). Gene interaction network studies to decipher the multi-drug resistance mechanism in Salmonella enteric serovar Typhi CT18 reveal potential drug targets. Microbial Pathogenesis, 142, 104096. https://doi.org/10.1016/j.micpath.2020.104096

  13. Naha, A., Miryala, S. K., Debroy, R., Ramaiah, S., & Anbarasu, A. (2020). Elucidating the multi-drug resistance mechanism of Enterococcus faecalis V583: A gene interaction network analysis. Gene, 144704. https://doi.org/10.1016/j.gene.2020.144704